Independent 12-Week Clinical Study

The AlphaCleanse study results are in.

The independent research lab Citruslabs ran a 12-week study in which 40 adults aged 40 to 65 took AlphaCleanse every day. Here is exactly what changed in their digestion, their energy, and their liver-related blood markers.

Run by Citruslabs 40 participants, ages 40 to 65 12 weeks

AlphaCleanse bottle with milk thistle, turmeric, ginger and spirulina in a studio setting

−38.6%

Digestive symptom score (GSRS)

p<0.0001

−24.0%

Fatigue score (MFI)

p<0.0001

+31.1%

Improvement in energy-level rating

p<0.0001

−10.6%

Alkaline phosphatase (liver blood marker)

p=0.0145

How to read these numbers. Every result compares week 12 to where each person started. On the symptom and fatigue scales a lower score is better, so a minus sign means things improved (energy is the exception, shown as its improvement). A p-value under 0.05 means the change is statistically significant, so it is very unlikely to be chance.

Digestive & Fatigue Outcomes

Improvements that grew stronger every month

Participants filled out two validated questionnaires at the start and again at weeks 4, 8, and 12: the Gastrointestinal Symptom Rating Scale (GSRS) for digestion and the Multidimensional Fatigue Inventory (MFI) for fatigue. On both, a lower score means fewer symptoms, so every result below is an improvement, and each one was statistically significant against baseline.

Digestive symptoms (GSRS)

36.6 at baseline, down to 22.4 by week 12 · improving from week 4 (−26.6%) onward

−38.6%p<0.0001

Fatigue (MFI)

59.1 at baseline, down to 44.9 by week 12

−24.0%p<0.0001

Feeling run-down or sick

How often, over the prior 4 weeks

−36.8%p<0.0001

Overall energy-level rating

Self-rated, up from 3.4 to 2.3 on a scale where a lower score means better energy

+31.1%improved · p<0.0001

Disrupted or difficult sleep

How often, over the prior 4 weeks

−30.5%p<0.0001

Daytime tiredness or sleepiness

How often, over the prior 4 weeks

−27.9%p<0.0001

Digestive symptom improvement vs baseline (GSRS)

Baseline

−26.6%

Week 4

−32.8%

Week 8

−38.6%

Week 12

What this means

Participants' digestive symptoms dropped by more than a third (GSRS −38.6%) and their fatigue by almost a quarter (MFI −24.0%), while they rated their own energy noticeably higher (+31.1%). Instead of leveling off, the improvements kept building from week 4 all the way to week 12.

Liver-Associated Blood Marker

A measurable change in the bloodwork

Everyone gave a blood sample at the start and again at week 12. One marker moved significantly: alkaline phosphatase, which is linked to liver health, fell from an average of 86.6 to 77.4 IU/L. The other liver markers (ALT, AST, albumin, and bilirubin) held steady over the 12 weeks.

Alkaline phosphatase (ALP)

86.6 down to 77.4 IU/L on average, baseline to week 12

−10.6%p=0.0145

What this means

Alkaline phosphatase, a marker tied to liver health, moved in a healthier direction. It was the only blood marker that changed significantly, and because a lab measured it rather than participants reporting it themselves, it is the most objective result in the study.

In Participants' Own Words

What people reported by week 12

At week 12, participants also rated their own experience. The figures below show how many agreed or strongly agreed with each statement. These are people's own impressions, not clinical measurements.

9 of 11product-experience statements reached ≥50% agreement by week 12

Experienced less bloating75.7%

Would like to keep using it75.7%

Would recommend to family & friends73.0%

More regular bowel movements70.3%

Improved digestive comfort62.2%

Feel physically fitter59.5%

Feel less sluggish56.8%

Overall health improved56.8%

Feel less irritable54.1%

Energy levels increased51.4%

What this means

What showed up on the scales showed up in daily life too. By week 12, 75.7% of participants said they felt less bloated, and 73% said they would recommend AlphaCleanse to family and friends.

What's Inside

Four botanicals behind the formula

AlphaCleanse pairs milk thistle and spirulina with ginger and turmeric, four botanicals long studied for their role in supporting liver and digestive function.

Milk Thistle

Silymarin, antioxidant support

Spirulina

Nutrient-rich algae

Ginger

Digestive support

Turmeric

Curcumin

How the Study Was Run

Independent, structured, and transparent

Adults aged 40 to 65 who reported low energy, fatigue, and digestive symptoms

12 wk

Daily use of two capsules once a day with the first meal

Check-ins at baseline, week 4, week 8, and week 12 using the validated GSRS and MFI questionnaires

2×

Blood panels at baseline and week 12 (ALT, AST, ALP, albumin, bilirubin)

Citruslabs, an independent clinical research organization, designed, ran, and analyzed the study. It was a single-arm study, which means everyone took AlphaCleanse and there was no placebo group. The analysis was done in GraphPad Prism, with significance set at p<0.05.

Feel the difference for yourself

AlphaCleanse blends milk thistle, spirulina, ginger, and turmeric to support healthy liver and digestive function.

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