D-Chiro-Inositol
D-Chiro-Inositol
D-chiro-inositol (DCI) is one of the body’s inositol isomers involved in insulin signaling. Human studies—especially in insulin-resistant states like PCOS—show that DCI can improve insulin sensitivity, ovulatory function, and metabolic markers. In glucose regulation, DCI complements myo-inositol by acting on downstream insulin pathways.
Why We Use it
At 50 mg, DCI supports healthy insulin signaling alongside myo-inositol 200 mg, reflecting evidence that combining isomers (often near a physiological ratio) can support metabolic balance more effectively than either alone.
Key Benefits
- Supports insulin signaling and sensitivity*
- Complements myo-inositol for balanced inositol physiology*
- Assists healthy glucose metabolism*
- Supports metabolic markers in insulin-resistant states*
- May help curb cravings via steadier glycemic response*
Different tissues favor different inositol isomers — muscle and liver utilize DCI-rich signaling, while ovaries favor myo-inositol.
Science-Backed Evidence
| Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. 1999. | Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, USA. | |
| The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. 2012. | Department of Medical Physiopathology, Sapienza University of Rome, Rome, Italy. | |
| The 40:1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios. 2019. | Department of Experimental Medicine, "Sapienza" University, Rome, Italy. |
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